PK-PD Analysis
An important aspect in drug development is the characterization of the drug-target pharmacokinetic (PK)-pharmacodynamic (PD) relationship. Pharmacodynamics describes the observed effect of a certain drug concentration on an organism, while pharmacokinetics describes the observed effects of the organism on the administered drug. The rationale for PK/PD-modelling is to link the blood concentration of the drug to the PET occupancy at a particular target to establish and characterize efficacy in terms of dose and PK concentration, and subsequently describe and predict the effect-time courses resulting from a drug dose.
Our experienced team of research scientists is trained and prepared to support project from pre-clinical to clinical trials, to derive EC50 estimation, assess direct versus indirect interactions, and predicting repeated dose occupancy from single dose occupancy (Figure 1).
Figure 1
