Preclinical Imaging

With strengths in instrument engineering, signal processing, and pharmaceutical R&D, Perceptive Discovery consistently delivers successful imaging study designs and executions.

Harness advanced imaging for faster, more informed decision-making.

Generate early data to support your research initiatives with Perceptive Discovery’s best-in-class preclinical imaging services. Our seamless approach across early-phase R&D saves you time and ensures consistency, helping you to identify the most promising compounds and minimize risk.

15+

Years of experience

Over 3K

Studies supported

8

Preclinical labs

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Why Choose Perceptive Discovery?

Premier Scientific Service

Trusted partner offering radiochemistry,
custom experimental design, execution,
and results interpretation.

Diverse Capabilities Across Therapeutic Areas

Adaptable approach to specialized
imaging biomarker studies.

Global Research Infrastructure

Multiple imaging facilities and strategic collaborations ensure agile study management
and expanded capabilities.

Collaborative Focus

Focus on collaboration ensures consistent growth, fostering long-term partnerships with sponsors.

Advanced Analysis Methods

Bespoke image analytics, pipelines, and
cutting-edge tools deliver precise, tailored
insights for sponsors.

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Key Therapeutic Areas

Neuroscience

Perceptive Discovery has vast preclinical experience supporting Neuroscience drug development. Our functional and molecular imaging solutions are well-suited for non-invasive longitudinal studies to provide multiple readouts, such as:

  • Biodistribution
  • Target engagement and occupancy
  • Neuropharmacodynamics
  • Neurotransmitter release
  • Biological therapeutics pharmacokinetics
  • Neuroinflammation
  • Neuromodulator analysis

Oncology

We use state-of-the-art imaging techniques to characterize the behavior of novel therapies and identify imaging biomarkers across diverse tumor model types (e.g. subcutaneous, orthotopic, metastatic).

Our core capabilities include:

  • Biodistribution of test articles
  • Target density and engagement
  • Pharmacokinetics (PK)
  • Pharmacodynamics (PD)
  • Tumor growth properties
  • Therapeutic efficacy

Radiopharmaceutical Therapy & Theranostics

Perceptive partners with sponsors to advance radiopharmaceutical therapy from proof-of-concept through late-phase trials. Our preclinical expertise in primary in vivo pharmacology services, radiochemistry, biodistribution, and dosimetry services supports optimized therapy development and accelerates progress toward first-in-human studies.

Our core capabilities include:​

  • Proof-of-concept studies to evaluate tumor targeting and anti-tumor activity
  • Radiolabeling and immunoreactivity method development for alpha, beta, and gamma isotopes
  • Biodistribution and dosimetry studies using imaging, gamma counting, and advanced analyses
  • Tailored clinical trial strategies focused on radiation safety, dosimetry, and patient selection
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Modalities and Models

Perceptive Discovery offers an array of preclinical services that deliver high-fidelity data and actionable insights to support informed decision-making.

From the intricacies of molecular processes to the complexity of whole-body systems, we are committed to harnessing the power of advanced technologies to develop imaging biomarkers, ensuring every study is equipped with the tools necessary.

We utilize a comprehensive range of animal models to ensure translational relevance, from small rodents to non-human primates (NHPs). These models are meticulously chosen, developed, and managed to provide relevant and translatable data across therapeutic areas.

Our in vivo and tissue/cell-based assays include:
In vivo Tissue/cell-based PET Autoradiography and microautoradiography SPECT Optical 2D and 3D cryotomography MRI Cryofluorescence tomography (CFT) Bioluminescence Blood and urine analysis Ultrasound Flow cytometry (FACS) Radioligand binding assay (cells and tissues)
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Expert Radiochemistry Services for Preclinical and Translational Studies

Radiolabeled compounds enable non-invasive evaluation of drug distribution, metabolism, and pharmacokinetics through PET and SPECT. Perceptive’s expertise in optimizing and synthesizing radiolabeled compounds ensures preclinical imaging studies are conducted with scientific rigor, accuracy, and safety, driving more efficient drug development.

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Image Analysis

Perceptive’s medical image analysis team specializes in developing advanced algorithms and pipelines to tackle complex image science challenges, extracting precise quantitative data for studies ranging from discovery research to late-phase clinical trials.

By combining the latest advancements in image science with engineering expertise, we innovate and refine new algorithms and automated and semi-automated image analysis processes
to ensure efficient, reliable analysis.

We support a range of preclinical image analysis tasks, tailoring our approach based on the species, imaging modalities, and therapeutic focus. Using our in-house software, including VivoQuant and iPACS, we apply existing tools or develop new ones to meet the specific needs of each study while offering sponsors convenient access to image data and results.

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VivoQuant: Advanced Image Processing and Analysis Software for Early Drug Development

VivoQuant is a powerful, vendor-neutral imaging software designed to deliver seamless image post-processing and 
analysis across multiple modalities and species. Engineered through collaboration with scientists, for scientists, VivoQuant empowers researchers by combining fundamental viewing functionality with powerful tools for fine-tuning images and isolating and analyzing regions of interest for quantitative 
analysis tailored to preclinical workflows.

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From Bench to Bedside: Discover Our In-House Imaging Clinics

With Perceptive’s translational imaging expertise, sponsors benefit from coordinated imaging protocol development across preclinical and first-in-human clinical studies.

Our streamlined approach saves time, reduces complexity, 
and supports regulatory success by delivering high-quality 
data and insights across translational research. Discover how 
our in-house imaging clinics in New Haven and London can advance your program.

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“We were very impressed with [Perceptive]. They were able to integrate our imaging needs and novel, complex models with their own expertise to generate a robust, high-quality data set in a timely fashion. We especially appreciated the weekly updates and the security of knowing our study was professionally monitored 24/7.  The entire [Perceptive] team is strong and an absolute pleasure to work with, we highly recommend their services and look forward to working with them again.”

Preclinical biotech company

How Can We Help?

Let’s discuss your next study.

Discover Our Clinical Trial Imaging Solutions

In-House Clinical and Imaging Centers

Highly established clinical and imaging centers supporting first-in-human and multicenter studies.

Imaging Core Lab

Proven expertise in delivering high-quality clinical trial imaging data at a global scale.