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Perceptive Imaging Services

Perceptive is a medical imaging service provider with over 300 scientists and over 110,000 qualified imaging centers and sites across the globe.  

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Clinical Trial Imaging Service Provider

We possess scientific and regulatory expertise, project management scale and operational excellence to manage all the clinical trial imaging components of your Phase I-IV clinical trials across the therapeutic spectrum and spanning imaging modalities. Our imaging core lab technology platforms support key decision-making in drug development by utilizing:

  • Site training and data harmonization
  • Patient screening and eligibility
  • Criteria-based centralized independent reviews and internal analysis
  • Confirmation of disease to ensure accurate patient management
  • Late-stage, multi-center determination of efficacy
  • Radiotracer supply chain and dose management capabilities
  • Advanced medical image analysis pipelines
Learn more - Radiopharmaceutical Therapy

Imaging Core Lab - Complete Project Support

Study Design

Deep scientific and medical expertise to support your study design.

Study Start-Up

Investigator meeting, site training and qualification, and documentation creation/development.

Image Management

Image submission and quality control via iPACS® – 21 CFR Part 11 Compliant.

Read Management

Images are queued for subspeciality readers (blinded reads) – 21 CFR Part 11 Compliant.

Image Analysis

Our team translates sophisticated, cutting-edge analytics into validated Core Lab workflows – 21 CFR Part 11 Compliant.

Data Management

Data delivery via common formats including CDISC and study specific reporting.

Contact a Solutions Specialist

Interested in learning more about our solutions? Our solutions specialists are here to answer any questions you have. Contact us and we’ll reach out to learn more about your needs.

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Clinical Imaging Core Lab Expertise

Oncology

Perceptive has the industry’s most extensive experience in oncology clinical trial imaging, having supported nearly 2,000 clinical trials across a broad range of indications. 

Validated Criteria Examples

  • PERCIST
  • RECIST 1.0/1.1
  • PCWG 2.0/3.0
  • RANO
  • LUGANO
  • IMWG
  • CHESON

Modified for Immuno-oncology

  • iRECIST
  • irRECIST
  • LYRIC
  • irRC

Central Nervous System (CNS)

  • 600+ clinical imaging trials managed
    • >200 AD and PD Studies with >56,000 subjects imaged
  • 90+ Phase I & II, multi-center trials conducted with PET, SPECT and MRI modalities
    • 1500+ imaging centers qualified worldwide
  • Two “in-house” clinical imaging centers with PET, SPECT and MRI capabilities
    • Development and application of 90+ novel neuro imaging agents
  • Redefining imaging analytic techniques
    • Amyloid, Tau and Dat IQ Analytics
    • SUV Generation
    • Centiloid Mapping

 

Reader Programs

Perceptive partners with leading institutions to select subspecialty radiologists, neuroradiologists and oncologists for our reader programs. We have a dedicated team that qualifies and selects readers to ensure that we have the most experienced professionals available to meet your study needs. All readers are trained according to your specific project requirements and performance is routinely monitored. Reads can be performed either as rolling reads as time points come in or batched and read as subjects come off study.

Different types of reads include:

  • Eligibility
    • 24-72 hour turnaround
  • Confirmation of progression
    • 24-72 hour turnaround
  • Safety
  • Double Read + Adjudication
  • Double Read + Adjudication + Oncologist Clinical Read
  • Consensus
  • Majority

Medical Image Analysis

Perceptive’s Medical Image Analysis team specializes in the evaluation of images to assess the performance of therapeutic and diagnostic agents. With more than 40,000,000 DICOM images analyzed, we have the expertise and scale to efficiently manage these processes to reduce variability and comply with regulatory requirements. At Perceptive, image science meets image engineering. Our industry leading medical image analysis team translates sophisticated, cutting-edge analytics into validated Core Lab workflows, including:

Quantitative Oncology

The medical image analysis team supports standard analysis of FDG PET imaging, including PERCIST and other SUV-based metrics, metabolic tumor volume and total lesion glycolysis. The image analysis team also specializes in developing and applying a broad range of tools to support advanced quantitative oncology tracer characterization and analytics across a broad range of modalities and studies. Examples include:

  • Powerful, multi-modal tumor and organ Segmentation tools
  • A range of flexible Biomathematical Modeling tools
  • Dosimetry calculations across radionuclide, administration route and species
  • Integrated Radiomics pipelines using standard and custom feature vectors
  • Preclinical and clinical support for Tracer Characterization
  • Sophisticated batch Image Triage and preprocessing methods

Neurology

The image analysis team provides industry-leading tools for Neuro PET, SPECT and MRI analysis supporting quantification projects from discovery research through late phase trials. Perceptive’s teams have analyzed thousands of clinical scans for Alzheimer’s Disease studies, utilizing validated SUVR pipelines, Centiloids and the state-of-the-art AmyloidIQ and TauIQ algorithms for Amyloid imaging and Tau imaging, respectively. Examples include:

  • The novel IQ Analytics suite for Tau Imaging, Amyloid Imaging and DaT Imaging
  • A range of flexible Biomathematical Modeling tools
  • Validated pipelines across multiple quantitative outcomes
  • Preclinical and clinical support for Tracer Characterization
  • Sophisticated batch Image Triage and preprocessing methods

Imaging Modalities

Perceptive’s imaging core lab is supported by iPACS®, our state-of-the-art image management platform. Utilizing a modality agnostic workflow to intake imaging data, we can QC, analyze and read a variety of imaging modalities, including:

PET/SPECT

Perceptive is an industry leader in managing Phase I-IV clinical trials utilizing PET & SPECT imaging to support trial objectives. Our expertise includes:
  • Imaging protocol development by Perceptive scientists, physicians and industry key opinion leaders
  • 1000+ PET qualified imaging centers in 35+ countries and 150+ SPECT qualified imaging centers in 15+ countries
  • Phantom analysis algorithms for site instrument assessment and performance metrics
  • Use of our internally developed iPACS software platform for fully web-based data submission, incorporating real-time conformity checks, configurable and automated study-specific workflows, and integrated query module
  • Real-time image data review by modality experts for adherence to imaging guidelines and site-specific approved parameters for data standardization and harmonization
  • Global network of expert radiologists and nuclear medicine physicians for study eligibility determination and drug efficacy assessments
  • Automated pipelines for objective, quantitative analysis of radiotracer distribution and localization fully validated for compliance regulatory guidelines

MRI

Perceptive has extensive expertise in conducting clinical MRI exploratory, disease modification and patient phenotyping/segregation studies.

  • Three in-house, state-of-the-art systems for advanced MRI in our London clinic
  • 475+ MRI qualified imaging sites in 25+ countries
  • Centers are required to acquire ACR MRI phantom data using specific to characterize scanner performance
  • Patient protocols are established and utilized for validation
  • Our team of scientists are also actively engaged in trials with novel modalities and techniques such as resting-state fMRI, phMRI, MRS, DCE-MRI, ALS-MRI

Others

Perceptive’s imaging core lab supports a variety of additional imaging modalities including:

  • CT
  • NM Bone Scan
  • Echo
  • X-ray, including Dynamic X-ray
  • Photography
  • Ultrasound

Manufacturing and Supply Chain Service

CHEMISTRY GROUP

Develop Chemistry Process and QC

  • Small molecules to Ab
  • Short to long-lived isotopes
  • PET, SPECT and theranostic applications

CHEMISTRY TECH TRANSFER

Global Manufacturing Site Setup

  • Regulatory knowledge base across geographies
  • Set-up and maintenance of 8 global Contract Manufacturing Organization sites

CLINICAL MANUFACTURING PHASE

Product Quality Management & Global Manufacturing

  • Complete supply chain management capabilities
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Learn about Perceptive's extensive imaging experience and capabilities in:

Oncology

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Central Nervous System

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Musculoskeletal

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Radiopharmaceuticals

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