Radiolabeling of a DOTA Conjugate Antibody for Theranostic Applications
A sponsor provided a monoclonal antibody conjugated to DOTA chelator through a surface lysine. Perceptive radiolabeled the DOTA-conjugate with both In-111 for SPECT imaging and Ac-225 for targeted alpha-therapy. Next, a rodent xenograph model was implanted with antigen-expressing tumor cells in one flank. SPECT imaging of In-111 labeled mAb showed accumulation of the radiotracer in the tumor. Administration of the Ac-225 labeled mAb showed a significant reduction of the tumor volume over time, compared to the control.
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