Perceptive - Your Imaging Partner for Parkinson’s Clinical Trials

Forging New Frontiers in PD Therapies

Welcome to the forefront of Parkinson’s disease (PD) research! At Perceptive, we provide a comprehensive suite of imaging services dedicated to advancing PD research and therapy development. 

Developing novel CNS therapies is a complex endeavor, requiring scientific rigor, medical expertise, and operational excellence. Our proven track record in supporting CNS Imaging studies reflects our commitment to transforming healthcare through innovative imaging and informatics. 

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Pioneers in Alzheimer’s and Parkinson’s Imaging

  • Redefining imaging informatics with PET, DaT SPECT as well as advanced MRI analysis.
  • Over 80,000 Alzheimer’s and Parkinson’s subjects imaged.
  • More than 200 studies conducted.
  • Expertise in developing, validating, and applying PET, SPECT, and MRI biomarkers.
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Parkinson’s Imaging Services

Industry-Leading Tools for Neuro PET, SPECT, and MRI Analysis

Preclinical Services:
Biodistribution Neuroinflammation Target engagement & occupancy studies Biological therapeutics Neuropharmacodynamics Pharmacokinetics Neurotransmitter and Neuromodulator Analysis Neurogenetics
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Early Phase (Phases I-IIa):

  • PET Imaging:
    • Radioligand dosimetry
    • Quantitative drug brain distribution
    • Target engagement
    • Drug concentration-target occupancy relationship
  • MRI Imaging:
    • Brain volumetric and cortical thickness analysis
    • Changes in brain activity and cerebral blood flow
    • Tissue microstructure and susceptibility analysis
    • Pharmacodynamic responses

Tracers Expertise:

  • 11C-PHNO – D2 dopamine receptor
  • 18F-AV-133 – VMAT2 (vesicular monoamine transporter)
  • 11C-UCB-J, 18F-SDM-8 – Sv2A tracers
  • 18F-BCPP-EF – Mitochondrial complex 1 (MC1) tracer

Late Phase Services:

  • Validated PET SUVR, DaT SPECT and advanced MRI pipelines.
  • IQ Analytics Imaging platform for increased power of studies. 
  • Complete project support from study design to imaging site qualification and management to data analysis.
  • Quantitative analysis for monitoring drug effects.
  • Semi-qualitative neuro-radiology reads for eligibility, safety and efficacy assessments. 
  • Image triage, preprocessing and management solutions.
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Advancing Parkinson’s Disease Diagnosis and Treatment

While Parkinson’s disease remains a clinical diagnosis, imaging studies play a critical role in differential diagnosis and research. Techniques such as DaT SPECT scans confirm parkinsonism and differentiate PD from secondary motor symptoms. Emerging advanced imaging modalities promise new biomarkers for diagnosing and tracking disease progression.

Future Directions

Ongoing research explores PET and SPECT tracers targeting dopamine biosynthesis, serotonin and acetylcholine receptors, and cerebral pathological protein deposits. The development of an α-synuclein tracer – the pathologic hallmark of PD – would revolutionize PD research. PET and SPECT analysis coupled with MRI approaches will enable better understanding of the disease pathophysiology and treatment effects. 

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Meet the Team

Our dedicated team of imaging experts and scientists combines scientific mastery with a deep understanding of Parkinson’s pathology to drive groundbreaking discoveries.

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Comprehensive Services

Imaging Solutions

  • MRI Imaging: High-resolution structural and functional imaging including but not limited to volumetric MRI, Diffusion Tensor Imaging (DTI), Neuro-Melanin (NM) MRI.
  • PET and SPECT Imaging: Molecular imaging with radioligand binding studies.

Biomarker Development

  • Blood-based and CSF biomarker discovery for early detection.
  • Analysis of inflammatory markers and oxidative stress.

Preclinical Models

  • Genetically modified rodent models mimicking Parkinson’s pathology.
  • Non-invasive imaging in primate models for translational research.

Data Analytics and Bioinformatics

  • Advanced image processing and AI-driven lesion detection.
  • Statistical modeling and integration of multi-omics data.

Clinical Trials Support

  • Centralized image review and analysis for multi-center trials.
  • Expert consulting and regulatory guidance.
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Why Choose Perceptive?

Expertise:

Teams with unparalleled knowledge in imaging, biomarker development, and preclinical models.

Technology:

State-of-the-art imaging tools and bioinformatics capabilities.

Collaboration:

Partnerships with academia, pharmaceutical companies, and research organizations.

Compliance:

Adherence to rigorous regulatory standards ensures reliable research data.

Choose Perceptive for unmatched expertise and cutting-edge technology to advance breakthroughs in PD research and therapy development.

Contact us today to discuss your specific needs and join us in forging new frontiers in Parkinson’s disease research.

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How Can We Help?

Reach out today and one of our solution experts will be in touch to learn about your specific needs.